Kristen Hanenian, APRN, ABAAHP on Instagram: "Same Hormones, Different Reactions: The COMT Effect!! COMT (catechol-O-methyltransferase) is an enzyme responsible for breaking down dopamine, norepinephrine, epinephrine, and estrogen metabolites. If you carry a COMT variant, especially a slow COMT, you don’t clear these compounds efficiently. The result can be heightened anxiety, irritability, sleep disruption, poor stress tolerance, headaches, and exaggerated reactions to caffeine, stimulants, or

MAO-B Inhibitors