vcclab.org. Overview of the many logP and other physical property calculators available commercially and on-line. XLOGP3, a simple LogP estimator used by PubChem (release 2021.05.07)

Nov 17, 2025 · LogP and logD are important values to consider during drug design as both give insight to the lipophilicity and hydrophilicity of compounds.

Jan 6, 2024 · LogP measures the logarithm of ration between the concentration of a compound in a non-polar solvent and in water. It is common practice to measure this using octanol (PubChem 2003) as …

LogP is the log of the partition coefficient of a solute between octanol and water, at near infinite dilution. LogP is widely used in drug discovery and development as an indicator of potential utility of a solute …

They are just two different methods for calculating logP. Log (p) (partition coefficient for n-octanol/water) - three fragmentation methods are used to predict the log (p) values.

Due to the importance of the drug lipophilicity, logP is a component of the Lipinski rule of five. 1 LogP is defined as the partition coefficient of a molecule between aqueous and lipophilic phases usually …

Introduction Symbols Definition of Partition Coefficient P and Distribution Coefficient D Micro Partition Coefficient Relation Between Macro and Micro Partition Coefficients LogP calculation methods …

LogP therefore provides a measure of the lipophilicity of a molecule. Lipophilicity is a key characteristic of drug molecules, affecting their absorption, distribution, metabolism and excretion (ADME). High …

Introduction Carefully planning chemical modification and labeling procedures includes determining the appropriate solvents for the specific reagents and reactants that will be used. Peptides and proteins …

Octanol-water partition coefficient logP is used in QSAR studies and rational drug design as a measure of molecular hydrophobicity. Hydrophobicity affects drug absorption, bioavailability, hydrophobic drug …