The San Francisco 49ers could be big buyers at the NFL trade deadline.

The Raiders are in a spot here after back-to-back losses to the Chiefs and Patriots. Buffalo presents yet another challenge for a defense that has managed just one turnover the last two weeks. Kirk Cousins has a 62.5% completion percentage in those losses. It will be tough to keep up with the Bills if the running game isn't there.

Dre Greenlaw's helmet-to-head hit on Ernest Jones earned a one-game NFL suspension, adding to the 49ers linebacker's growing disciplinary record.

QB Brock Purdy falls to No. 2 in NFL.com's quarterback rankings as Bills star Josh Allen takes the top spot after an impressive Monday night win.

One projection has San Francisco beating Kansas City 24-20 in February, with Brock Purdy taking home Super Bowl MVP honors.

Coming off a week in which the biggest favorite burned their backers, here are four options to consider that don't fit the same mold.

The 49ers remain undefeated at 5-0 and dominate Week 6 NFL power rankings after beating the Seahawks, with multiple outlets calling them the NFL's best team.

The San Francisco 49ers and Seattle Seahawks will renew their NFC West rivalry on Sunday, October 11, in a matchup between two teams looking to strengthen their position in one of the NFL’s most competitive divisions.