Congenital heart defects (CHD) represent the most common congenital malformations globally and constitute a leading cause of neonatal mortality, with early maternal risk factors playing significant ...

Modern hip replacements are nearly twice as likely as older hip replacements to last at least 25 years, suggests a study ...

Many of our colleagues sought guidance on the process, tools, and expectations for systematic reviews—a methodology increasingly adopted in fields such as biomechanics, communication disorders, ...

Molecularly targeted therapies are increasingly relevant in clinical oncology, as they enable the selective modulation of specific biologic targets—such as enzymes or receptors—by inhibiting or ...

Objective To understand the associations of trajectories and accumulation of physical activity (PA) over adulthood with all-cause, cardiovascular disease (CVD), and cancer mortality. Design Systematic ...

Changes in the vaccine advisory process in the United States have disrupted immunization guidance, which reinforces the need for independent evidence review to inform decisions regarding immunization ...

Objective To evaluate systematic reviews of randomised controlled trials (RCTs) on the effects of exercise on general cognition, memory and executive function across all populations and ages. Methods ...

Introduction Child stunting, a measure of malnutrition, is a major global health challenge affecting 148.1 million children in 2022. Global stunting rates have declined from 47.2% in 1985 to 22.3% in ...

Context Health consumer escalation of acute deterioration response systems are now widely available to help facilitate early recognition and response to acute deterioration in hospitals. Yet, a ...